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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Eduardo Rúbio# | 97 | 2010-2015 | |
| 2 | Willie Hogan | 96 | 1996-2001 | |
| 2 | Lance Manning | 96 | 2017-2020 | |
| 4 | Wilson Cotton | 93 | 2003-2009 | |
| 5 | Jud Mullins | 92 | 2010-2014 | |
| 6 | Johan Garo | 91 | 2002-2012 | |
| 7 | Jorge López | 90 | 1996-2000 | |
| 8 | Ánibal Rivera | 88 | 1999-2003 | |
| 9 | Kyle Barnes | 85 | 2012-2017 | |
| 9 | Calvin Miles | 85 | 2009-2014 | |
| 11 | Sergio Rodríguez# | 80 | 2012-2015 | |
| 12 | Bill Saunders | 78 | 2016-2020 | |
| 13 | Sixto Díaz | 77 | 2003-2006 | |
| 13 | Juan Rodríguez | 77 | 2008-2011 | |
| 15 | Jim Williams | 76 | 2004-2007 | |
| 16 | José Fuentes | 75 | 2003-2007 | |
| 16 | Raúl Gómez | 75 | 2004-2008 | |
| 16 | Greg Gregory | 75 | 2012-2016 | |
| 19 | Brian Montgomery | 74 | 2010-2016 | |
| 19 | Alfonso Negrete | 74 | 2017-2020 | |
| 21 | Robby Clark | 72 | 2002-2005 | |
| 21 | Juan Delgado | 72 | 2005-2008 | |
| 21 | Jorge Moreno | 72 | 2007-2014 | |
| 21 | Carlos Nodar | 72 | 2001-2005 | |
| 25 | Jeff Farris | 71 | 1994-1999 | |
| 25 | Powell Sims | 71 | 2018-2020 | |
| 27 | Salvador Mesa | 70 | 2002-2006 | |
| 28 | Rafael Cardenas | 69 | 2017-2020 | |
| 28 | Merlin Robinson | 69 | 2009-2014 | |
| 30 | David Salgado | 68 | 2008-2011 | |
| 31 | Bruce Dyer | 67 | 2010-2016 | |
| 31 | Jerry Lewis | 67 | 2012-2016 | |
| 31 | Cristóbal Ortíz | 67 | 2003-2006 | |
| 31 | Rob Spence | 67 | 2010-2015 | |
| 31 | Chris Thomas# | 67 | 2018-2021 | |
| 36 | Mathew Bruce | 66 | 2012-2015 | |
| 36 | Alex Carey | 66 | 2012-2016 | |
| 36 | Javier López | 66 | 2001-2007 | |
| 36 | Joe O'Halloran | 66 | 1998-2000 | |
| 36 | Bill Parker | 66 | 2005-2009 | |
| 36 | Félix Salazar | 66 | 2008-2013 | |
| 36 | Fernando Salazar | 66 | 2013-2017 | |
| 43 | José Torres | 65 | 2015-2020 | |
| 43 | Lester Wilson | 65 | 2008-2011 | |
| 45 | Kieran Harris | 64 | 2009-2015 | |
| 45 | Ramiro Martínez | 64 | 2016-2018 | |
| 45 | Carlos Pacheco | 64 | 1996-2000 | |
| 45 | Jesús Rodríguez | 64 | 2012-2015 | |
| 45 | Carlos Santos | 64 | 2017-2021 | |
| 45 | Edgardo Suárez | 64 | 1977-1981 | |
| 45 | Blake Watts# | 64 | 2016-2018 | |
| 52 | Aurelio Alomar | 63 | 1999-2005 | |
| 52 | Juan Gonzáles | 63 | 2007-2010 | |
| 52 | Christian Hamilton | 63 | 1970-1977 | |
| 52 | Tom Hendricks | 63 | 2016-2020 | |
| 52 | Pedro Pérez | 63 | 2015-2021 | |
| 52 | Frank Preston | 63 | 2015-2018 | |
| 52 | Alfredo Valdéz | 63 | 1996-2000 | |
| 52 | Jack Veeck | 63 | 2005-2011 | |
| 60 | Joe Dawson | 62 | 2017-2019 | |
| 60 | Jaime Enríquez | 62 | 2000-2003 | |
| 60 | Manny Hernández | 62 | 2010-2016 | |
| 60 | Tim Lee | 62 | 2008-2011 | |
| 60 | Dave McDonald | 62 | 2002-2008 | |
| 60 | Benjamin McNeil | 62 | 1980-1983 | |
| 66 | Ronald Johnson | 61 | 1996-2000 | |
| 66 | Dale Jones | 61 | 2000-2002 | |
| 66 | Carlos Murphy | 61 | 1996-1999 | |
| 66 | Jeffrey Richards | 61 | 2010-2015 | |
| 66 | Stanley Simpson | 61 | 2008-2014 | |
| 71 | Jimmy Jackson# | 60 | 2019-2022 | |
| 71 | Robby MacIntyre | 60 | 2000-2005 | |
| 71 | Félix Mercado# | 60 | 2014-2018 | |
| 71 | Jerome Patterson | 60 | 2017-2021 | |
| 71 | Donnie Stewart | 60 | 2009-2015 | |
| 76 | George Hull | 59 | 1978-1981 | |
| 76 | Joe Mathis | 59 | 2012-2019 | |
| 76 | Chris Reeves | 59 | 1996-2001 | |
| 76 | Kang Zha | 59 | 2013-2016 | |
| 80 | Don Chavers | 58 | 2016-2019 | |
| 80 | Robert Frost | 58 | 2009-2014 | |
| 80 | Paul Gibson | 58 | 2012-2015 | |
| 80 | Frank Henderson# | 58 | 2017-2019 | |
| 80 | Ricky O'Higgins | 58 | 2008-2011 | |
| 80 | Salvador Rojas | 58 | 2012-2015 | |
| 86 | Travis Adams | 57 | 2005-2007 | |
| 86 | Dani Cortéz | 57 | 2003-2005 | |
| 86 | Pedro García | 57 | 2016-2020 | |
| 86 | Matt Lilly | 57 | 1993-1996 | |
| 86 | Kotu Okeyo | 57 | 1999-2005 | |
| 86 | John Pearl | 57 | 1977-1981 | |
| 86 | José Pérez | 57 | 2011-2015 | |
| 93 | Willard Ford | 56 | 2003-2008 | |
| 93 | Francisco Ramírez | 56 | 2003-2009 | |
| 93 | Landon Sellers | 56 | 2002-2005 | |
| 93 | Lorenzo Vélez | 56 | 1991-2000 | |
| 93 | Chris Young | 56 | 2003-2006 | |
| 98 | Lyle Moore | 55 | 1999-2001 | |
| 98 | Ed Tate | 55 | 1988-1991 | |
| 98 | Juan Villalobos | 55 | 2002-2005 |
