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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | José García | 1.623 | 1984 | |
| 2 | Erik McConnell | 1.666 | 1979 | |
| 3 | José Flores | 1.806 | 1970 | |
| 4 | Jorge Saldaña | 1.876 | 1977 | |
| 5 | Ernie Spence | 2.061 | 1973 | |
| 6 | Nick Nance | 2.083 | 1975 | |
| 7 | Mike Sullivan | 2.154 | 1988 | |
| 8 | José Gallardo | 2.189 | 1982 | |
| 9 | Tom Sheffield | 2.191 | 1988 | |
| 10 | Dave McDonald# | 2.209 | 2021 | |
| 11 | Emílio Vázquez | 2.212 | 1993 | |
| 12 | Jesús Sánchez | 2.269 | 1971 | |
| 13 | Cam Halfyard | 2.337 | 2008 | |
| 14 | Carlos Gómez | 2.340 | 1976 | |
| 15 | Sergio Vargo | 2.479 | 1970 | |
| 16 | Jaime Navarro | 2.481 | 1970 | |
| 17 | Dale Bader | 2.489 | 1975 | |
| 18 | José Estrada | 2.493 | 1971 | |
| 19 | Robert Hathaway | 2.496 | 1975 | |
| 20 | Dave Hall | 2.523 | 1977 | |
| 21 | Ryan Lawson | 2.525 | 1982 | |
| 22 | Richard Shannon | 2.528 | 2000 | |
| 23 | Vincente Francisco | 2.534 | 1970 | |
| 24 | Juan Castillo | 2.538 | 1971 | |
| 25 | Gabriel Espinoza | 2.545 | 1972 | |
| 26 | Mark Williams | 2.548 | 1996 | |
| 27 | Francisco Sepúlveda | 2.569 | 1970 | |
| 28 | Bob Wiederanders | 2.570 | 1977 | |
| 29 | Bret Mason# | 2.594 | 2017 | |
| 30 | Roberto Estrada | 2.598 | 1994 | |
| 31 | Alberto Delgado | 2.626 | 1974 | |
| 32 | Richard Corbin | 2.636 | 1973 | |
| 33 | Miguel Vela | 2.640 | 1974 | |
| 34 | Dave Jackson | 2.652 | 1971 | |
| 35 | Jeffery Newman | 2.657 | 1973 | |
| 35 | Don Boyd# | 2.657 | 2017 | |
| 37 | Gabriel Espinoza | 2.658 | 1973 | |
| 38 | Nick Martin | 2.666 | 1974 | |
| 39 | Jesús Hernández | 2.667 | 1998 | |
| 39 | Matt Lee | 2.667 | 1970 | |
| 41 | Gabriel Espinoza | 2.675 | 1970 | |
| 42 | Bob Peterson | 2.691 | 1981 | |
| 43 | Griff Ellacott | 2.695 | 1997 | |
| 44 | Albert García | 2.700 | 1975 | |
| 44 | Louie Campbell | 2.700 | 1972 | |
| 44 | Tomás Valle | 2.700 | 1988 | |
| 47 | Lucas Park | 2.707 | 1993 | |
| 48 | José Rodgers | 2.716 | 1972 | |
| 49 | Luis Sánchez | 2.719 | 1994 | |
| 50 | Carlos Pacheco | 2.722 | 1997 | |
| 51 | José Flores | 2.724 | 1973 | |
| 52 | Lindsay Collins | 2.726 | 1998 | |
| 53 | Clinton Benson | 2.727 | 2014 | |
| 54 | Stanley Hudson | 2.743 | 1972 | |
| 55 | Sergio Torres | 2.744 | 1977 | |
| 56 | Jason Williams | 2.751 | 1973 | |
| 57 | Juan Díaz | 2.766 | 1970 | |
| 58 | Chris Collins | 2.769 | 1978 | |
| 59 | Kent Ward | 2.780 | 1973 | |
| 60 | Alfonso Pérez | 2.781 | 1975 | |
| 61 | Ron Anderson | 2.811 | 1981 | |
| 62 | Bob Scott | 2.814 | 1981 | |
| 63 | Jason Ward | 2.817 | 1978 | |
| 64 | Barton Spearman# | 2.829 | 2019 | |
| 65 | Joseph Carter | 2.842 | 1970 | |
| 66 | Ken Chambers | 2.865 | 1977 | |
| 67 | Willie St. John# | 2.877 | 2013 | |
| 68 | Claudio Caballero | 2.893 | 1984 | |
| 69 | Brandon McVanish | 2.897 | 1997 | |
| 70 | Vicente Rodríguez | 2.900 | 2009 | |
| 71 | Steve Burke | 2.902 | 1970 | |
| 72 | Jim O'Gagarty | 2.919 | 2010 | |
| 73 | Ken Shelton | 2.930 | 1996 | |
| 74 | Donald Brown | 2.941 | 1970 | |
| 75 | Dennis Miller | 2.945 | 1980 | |
| 76 | William Sundberg | 2.952 | 1975 | |
| 77 | Glenn May | 2.966 | 1979 | |
| 78 | Ken Moore | 2.968 | 1973 | |
| 79 | Shawn Booker | 2.977 | 1993 | |
| 80 | Juan Marín | 2.978 | 1997 | |
| 81 | Todd Shaw | 2.980 | 1974 | |
| 82 | Jim Wyatt | 2.990 | 1971 | |
| 83 | Yakamochi Yamasaki | 2.994 | 1970 | |
| 84 | Sadaharu Sato | 3.005 | 2014 | |
| 85 | Doyle Thomas | 3.016 | 1978 | |
| 86 | Erik Baxter# | 3.017 | 2019 | |
| 87 | David Cavazos | 3.018 | 1984 | |
| 88 | Carl Hill | 3.023 | 1999 | |
| 89 | Quentin Allen | 3.035 | 1999 | |
| 89 | Miguel Rivera | 3.035 | 1979 | |
| 91 | Marcos Cuellar | 3.037 | 1970 | |
| 92 | Tim Knapp | 3.038 | 1972 | |
| 93 | Terry Carter | 3.039 | 1970 | |
| 94 | Chris Burnett | 3.048 | 1994 | |
| 95 | Kiyohira Tsukamoto | 3.055 | 1982 | |
| 96 | Juan Vargas | 3.057 | 1980 | |
| 97 | Gerard Reed# | 3.065 | 2019 | |
| 98 | Bob Peterson | 3.069 | 1979 | |
| 99 | Rafael González | 3.071 | 1973 | |
| 100 | Jesús Ornelas | 3.073 | 1979 |
