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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Maurice Watson | 77 | 2011-2015 | |
| 2 | Dave Dukes | 71 | 1998-2001 | |
| 3 | Juan Hinojosa | 70 | 2000-2005 | |
| 3 | Leroy Smith# | 70 | 2017-2018 | |
| 5 | Dan Campbell | 69 | 1998-2005 | |
| 6 | Steve Franklin | 68 | 2006-2013 | |
| 6 | Harvey Mote | 68 | 2007-2015 | |
| 8 | Júlio Romero# | 64 | 2016-2018 | |
| 9 | Reynaldo Rosas | 61 | 2000-2004 | |
| 10 | Alfonso Ramírez | 58 | 2003-2009 | |
| 10 | Miguel Angel Rodríguez | 58 | 1997-2004 | |
| 12 | Tom Massey | 55 | 2013-2014 | |
| 13 | Enrique Méndez# | 54 | 2017-2022 | |
| 14 | Nelson Murphy | 52 | 2017-2021 | |
| 14 | Juan Santana | 52 | 2006-2011 | |
| 16 | Lynn Dearborn | 50 | 2001-2005 | |
| 16 | Andy Fitzgerald | 50 | 2001-2008 | |
| 18 | José Berau | 49 | 1997-2001 | |
| 18 | Bob Fuller | 49 | 2003-2004 | |
| 18 | Jason Ríos | 49 | 2001-2002 | |
| 21 | Nelson Adams | 48 | 2004-2009 | |
| 21 | Jeff Miller | 48 | 2002-2004 | |
| 21 | António Negrete | 48 | 2001-2008 | |
| 21 | Jesús Romero | 48 | 1997-2003 | |
| 21 | Shinsaku Sato | 48 | 1994-2000 | |
| 26 | Ron Sepkiechler | 47 | 1979-1981 | |
| 26 | Tom Wilcox | 47 | 1998-2003 | |
| 28 | Mike Huber | 46 | 1996-2005 | |
| 28 | Jesús Moreno | 46 | 2008-2014 | |
| 28 | Chris Schmidt# | 46 | 2021-2023 | |
| 28 | Karl Truax | 46 | 1979-1982 | |
| 32 | Kane Maddox | 45 | 1996-2004 | |
| 32 | Dave Manning | 45 | 2001-2002 | |
| 32 | Jim Rice# | 45 | 2022-2023 | |
| 32 | Aurelio Rosas | 45 | 2014-2016 | |
| 36 | Martin Jones# | 44 | 2017-2021 | |
| 36 | Lanny MacFadden | 44 | 2011-2015 | |
| 36 | Pedro Rodríguez | 44 | 2000-2007 | |
| 36 | Juan Solís | 44 | 1992-1997 | |
| 36 | Ignacio Torres# | 44 | 2015-2017 | |
| 36 | Lee Walton | 44 | 1999-2001 | |
| 42 | George Barrett | 43 | 2014-2017 | |
| 42 | Carlos Cortéz | 43 | 2006-2008 | |
| 42 | John King | 43 | 2000-2001 | |
| 42 | John Mitchell# | 43 | 2021-2022 | |
| 42 | Paul O'Halloran# | 43 | 2015-2016 | |
| 42 | James Rigney | 43 | 1995-2003 | |
| 48 | Chris Cook | 42 | 2010-2014 | |
| 48 | Artie Ervin | 42 | 2002-2003 | |
| 48 | Juan García | 42 | 2003-2009 | |
| 48 | José Ocampo | 42 | 2004-2013 | |
| 48 | Craig Wiggins | 42 | 1979-1983 | |
| 53 | Kevin Hampton | 41 | 2015-2019 | |
| 53 | Félix Hernández# | 41 | 2015-2016 | |
| 53 | Steve Rogers | 41 | 2000-2001 | |
| 53 | Rick Wiggins | 41 | 2000-2008 | |
| 57 | Julián Araica | 40 | 2015-2016 | |
| 57 | Chris Henderson# | 40 | 2016-2017 | |
| 57 | Eric Johnson# | 40 | 2015-2016 | |
| 57 | Pedro Juárez# | 40 | 2021-2023 | |
| 57 | António Lópes | 40 | 1999-2001 | |
| 57 | Nolan Miller | 40 | 2006-2012 | |
| 57 | Dan Quick | 40 | 1995-1998 | |
| 57 | Marcos Salinas | 40 | 1978-1983 | |
| 57 | Darby Stone | 40 | 2014-2018 | |
| 66 | Jeremiah Faulkner | 39 | 2005-2009 | |
| 66 | Ed Horwood | 39 | 2002-2006 | |
| 66 | Denis Johnson | 39 | 2005-2008 | |
| 66 | Jason Morgan | 39 | 1997-2002 | |
| 66 | John Morrison | 39 | 1997-2004 | |
| 66 | Martin Sterling | 39 | 2000-2001 | |
| 66 | Jeff Wood# | 39 | 2021-2022 | |
| 73 | Mike Alexander | 38 | 2012-2017 | |
| 73 | Arturo Anaya | 38 | 2004-2009 | |
| 73 | Johnny Anderson# | 38 | 2019-2020 | |
| 73 | Shawn Boone | 38 | 2009-2012 | |
| 73 | Manny Chacón | 38 | 1970-1972 | |
| 73 | Ron Gowdy | 38 | 1997-1999 | |
| 73 | Clyde Jones | 38 | 1995-2000 | |
| 73 | António Ortíz | 38 | 1994-1999 | |
| 73 | John Richardson | 38 | 2001-2002 | |
| 73 | Sherman Scott | 38 | 2014-2020 | |
| 83 | José Aleyándrez | 37 | 1998-2003 | |
| 83 | Marvin Bush | 37 | 2004-2006 | |
| 83 | Iván Guilarte | 37 | 1995-1999 | |
| 83 | Casey Harris | 37 | 2005-2013 | |
| 83 | Thom Holden | 37 | 2000-2006 | |
| 83 | Pedro Lara# | 37 | 2021-2023 | |
| 83 | Miguel Maestas | 37 | 2007-2014 | |
| 83 | Roberto Pérez | 37 | 1982-1988 | |
| 83 | Juan Ramos | 37 | 1999-2001 | |
| 83 | Chuck Rich | 37 | 1978-1983 | |
| 83 | Henry Walker | 37 | 2009-2015 | |
| 83 | Ken Whitfield | 37 | 2001-2006 | |
| 83 | Arnold Wilcox# | 37 | 2016-2017 | |
| 96 | Juan Acevado | 36 | 2002-2003 | |
| 96 | Ángel Castro# | 36 | 2021-2023 | |
| 96 | Eric Cornett | 36 | 2000-2007 | |
| 96 | Juan Carlos Cruz | 36 | 1992-1997 | |
| 96 | Dave Dundee# | 36 | 2022-2022 |
