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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Pablo Cruz | 1.404 | 2006 | |
| 2 | Larry Kelley | 1.569 | 1992 | |
| 3 | Mac Smart | 1.648 | 1973 | |
| 4 | Ignacio Cole | 1.705 | 2015 | |
| 5 | Brendon Crocker | 1.714 | 1992 | |
| 6 | Ricardo Toro | 1.735 | 2010 | |
| 6 | Russell Owens | 1.735 | 2008 | |
| 8 | Danny Moore | 1.771 | 2010 | |
| 9 | Ken Hunter | 1.781 | 1992 | |
| 10 | Ron King# | 1.800 | 2013 | |
| 11 | Phil Bush | 1.811 | 1996 | |
| 12 | Jason Hunter | 1.852 | 1997 | |
| 13 | Juan Hernández | 1.867 | 1994 | |
| 14 | Paul Morgan | 1.915 | 1993 | |
| 15 | Júlio Castillo | 1.952 | 1982 | |
| 16 | Larry Hendrix | 2.018 | 2015 | |
| 17 | Jeff Thomas | 2.063 | 1997 | |
| 18 | José Martínez | 2.093 | 1979 | |
| 19 | Cooper Waddell | 2.103 | 2010 | |
| 20 | Henry Olsen | 2.106 | 1972 | |
| 20 | Roberto Lima# | 2.106 | 2020 | |
| 22 | Francisco Deleón | 2.117 | 1996 | |
| 23 | Bob Schneider | 2.153 | 1997 | |
| 24 | Jeff Thomas | 2.167 | 1996 | |
| 25 | Michael Ferán | 2.192 | 1974 | |
| 26 | Flynn Brooks | 2.193 | 1980 | |
| 26 | Steve Cochran | 2.193 | 1972 | |
| 28 | Steven Hawkins | 2.205 | 1987 | |
| 29 | Rob Buck | 2.210 | 1992 | |
| 30 | Cedric Barnes# | 2.211 | 2017 | |
| 31 | Derek Davis | 2.214 | 1992 | |
| 32 | Roberto García | 2.217 | 1980 | |
| 33 | Curt Palmer | 2.254 | 2007 | |
| 34 | Glenn Martin# | 2.261 | 2011 | |
| 35 | Armando Hernández | 2.263 | 1982 | |
| 36 | Don Underwood | 2.266 | 1976 | |
| 37 | Steve Johnson | 2.293 | 1998 | |
| 38 | Anastasio Gonzáles | 2.304 | 1985 | |
| 38 | Domingo Reynoso | 2.304 | 1998 | |
| 40 | Mark Cates | 2.310 | 1981 | |
| 41 | Jon Williams | 2.324 | 2013 | |
| 42 | Domingo Reynoso | 2.329 | 1997 | |
| 43 | John Campbell# | 2.330 | 2010 | |
| 44 | Richie Davidson | 2.331 | 2013 | |
| 45 | Phil Keys | 2.338 | 1982 | |
| 46 | Paul Gillespie | 2.352 | 2011 | |
| 47 | Pablo López | 2.354 | 2010 | |
| 48 | Fernando Morales | 2.364 | 1995 | |
| 49 | Gene Warrick | 2.366 | 1973 | |
| 50 | Markus Young | 2.372 | 2015 | |
| 51 | Jim Jones | 2.375 | 1979 | |
| 52 | Dennis Anderson | 2.396 | 1992 | |
| 53 | Chester Dallimore | 2.403 | 2006 | |
| 54 | Henry Browning | 2.430 | 1995 | |
| 55 | José Cháves | 2.445 | 2012 | |
| 56 | Ramón Ruíz | 2.477 | 1999 | |
| 57 | Augusto Haciento | 2.478 | 2013 | |
| 58 | Alexander Patterson | 2.479 | 2011 | |
| 59 | Joselito Valverde | 2.494 | 1975 | |
| 60 | Nelson Marino# | 2.499 | 2017 | |
| 61 | Andre Hamilton | 2.502 | 1978 | |
| 62 | James Parsons | 2.509 | 2014 | |
| 62 | Shane Palfrey | 2.509 | 1976 | |
| 64 | Millard Major | 2.514 | 1978 | |
| 65 | Luis Leyva | 2.523 | 1997 | |
| 66 | Kendrick Jackson | 2.536 | 1979 | |
| 67 | Arturo Jiménez | 2.550 | 1974 | |
| 68 | Paul Wilkins | 2.551 | 2011 | |
| 69 | Pancho Ruíz | 2.553 | 1981 | |
| 70 | Dave Long | 2.561 | 1992 | |
| 71 | George Glendenning | 2.571 | 1985 | |
| 72 | Luis Rodríguez | 2.575 | 1984 | |
| 73 | Manuel Rodríguez | 2.577 | 1976 | |
| 74 | Pat McClendon# | 2.579 | 2008 | |
| 75 | Luis Luna# | 2.590 | 2012 | |
| 76 | José Evans | 2.595 | 1993 | |
| 76 | Pedro Morán | 2.595 | 2011 | |
| 78 | Joseph Peck | 2.597 | 2013 | |
| 78 | Jack Leonard | 2.597 | 1990 | |
| 80 | Victor Almond | 2.599 | 1998 | |
| 81 | Phil Booth | 2.607 | 2011 | |
| 82 | Cameron Faulkner# | 2.611 | 2020 | |
| 83 | Lucas Welch | 2.617 | 1986 | |
| 84 | Manuel Calderón | 2.628 | 2013 | |
| 85 | David Thomas | 2.635 | 1972 | |
| 86 | Dale Reese | 2.641 | 1994 | |
| 87 | Habrăo Vila | 2.644 | 2013 | |
| 88 | Stephen Hess | 2.645 | 1999 | |
| 89 | José Garza | 2.649 | 1972 | |
| 90 | Chet Keys | 2.651 | 1998 | |
| 91 | Pedro Chávez | 2.653 | 1976 | |
| 92 | Donald Forrest | 2.656 | 1993 | |
| 93 | Hidetoshi Kichida | 2.657 | 1994 | |
| 94 | José González# | 2.659 | 2014 | |
| 95 | Jim Smith# | 2.664 | 2012 | |
| 96 | Charles Ferguson | 2.665 | 1998 | |
| 97 | Ernesto Martínez | 2.670 | 1976 | |
| 97 | Reid Erickson# | 2.670 | 2020 | |
| 97 | Shannon Turner | 2.670 | 1973 | |
| 100 | Ed Hartley | 2.681 | 1985 |
