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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sáenz, Steve | SP | Wilmington Hogs | 25 | 10/09/1998 | Gloversville | USA | Switch | Right | 5' 9" | 180 lbs | - |
| Sakei, Shusaku | C | Free Agent | 28 | 05/04/1995 | Kobe | JPN | Left | Right | 6' 0" | 235 lbs | - |
| Salazar, Jorge | SP | Winston-Salem Wheelers | 22 | 11/18/2001 | Chambas | CUB | Left | Right | 6' 0" | 185 lbs | - |
| Salazar, Lúcio | CL | Free Agent | 25 | 12/13/1998 | Hickory | USA | Left | Left | 6' 3" | 230 lbs | - |
| Sánchez, Ángel | SP | Myrtle Beach Knockouts | 22 | 03/26/2001 | Santa Maria | USA | Left | Left | 6' 5" | 215 lbs | - |
| Sánchez, Mario | RP | Free Agent | 26 | 04/03/1997 | Santo Domingo | DOM | Right | Right | 6' 2" | 210 lbs | - |
| Sanford, Jeff | RF | Winston-Salem Wheelers | 22 | 06/30/2001 | Whittier | USA | Switch | Right | 6' 4" | 200 lbs | - |
| Sanford, Shaun | 1B | Free Agent | 30 | 05/20/1993 | Edgemere | USA | Right | Right | 6' 6" | 275 lbs | - |
| Schmidt, Neal | RF | Lynchburg Wallabies | 23 | 12/23/2000 | North Tonawanda | USA | Right | Right | 6' 0" | 195 lbs | - |
| Scott, Eric | 3B | Myrtle Beach Knockouts | 26 | 06/25/1997 | Indianapolis | USA | Right | Right | 6' 3" | 205 lbs | - |
| Sellers, Mark | RP | Free Agent | 25 | 06/26/1998 | El Cajon | USA | Switch | Left | 6' 1" | 185 lbs | - |
| Sellick, Bill | LF | Lynchburg Wallabies | 22 | 03/09/2001 | Edmonton | CAN | Right | Right | 6' 0" | 190 lbs | - |
| Serna, Alberto | 1B | Kinston Saloons | 26 | 05/11/1997 | Coral Springs | USA | Right | Right | 6' 2" | 205 lbs | - |
| Serrano, Jesús | RP | Kinston Saloons | 22 | 04/03/2001 | El Jícaro | NCA | Right | Left | 6' 3" | 175 lbs | - |
| Shafer, Tom | CF | Free Agent | 29 | 04/28/1994 | Berkeley Heights | USA | Right | Right | 6' 2" | 215 lbs | - |
| Sharp, Steve | 1B | Free Agent | 27 | 11/13/1996 | Newark | USA | Right | Right | 6' 7" | 225 lbs | - |
| Shields, Joe | CL | Salem Cannibals | 22 | 09/12/2001 | Lufkin | USA | Right | Right | 6' 4" | 200 lbs | - |
| Simmons, Monty | RP | Free Agent | 25 | 06/12/1998 | Wheeling | USA | Right | Right | 6' 2" | 205 lbs | - |
| Sims, Alex | RF | Winston-Salem Wheelers | 24 | 11/02/1999 | Mingo Junction | USA | Right | Right | 6' 1" | 185 lbs | - |
| Smith, Doug | 3B | Wilmington Hogs | 22 | 02/14/2001 | New York | USA | Right | Right | 5' 9" | 165 lbs | - |
| Smith, Herman | 2B | Free Agent | 26 | 08/25/1997 | Los Angeles | USA | Right | Right | 6' 0" | 205 lbs | - |
| Snow, Bruce | SP | Wilmington Hogs | 20 | 03/08/2003 | Stuarts Draft | USA | Right | Right | 6' 4" | 200 lbs | - |
| Snyder, Earl | SP | Lynchburg Wallabies | 23 | 08/09/2000 | Houston | USA | Right | Left | 6' 6" | 220 lbs | - |
| Solís, Jesús | 2B | Wilmington Hogs | 24 | 02/03/1999 | Shafter | USA | Right | Right | 6' 0" | 195 lbs | - |
| Solís, Juan | RP | Potomac Blue Demons | 25 | 05/11/1998 | Chesapeake | USA | Right | Right | 6' 3" | 220 lbs | - |
| Sorensen, Will | RP | Kinston Saloons | 27 | 02/20/1996 | Indianapolis | USA | Switch | Right | 6' 0" | 190 lbs | - |
| Sosa, Cipriano | CF | Winston-Salem Wheelers | 21 | 06/24/2002 | San Nicolas de los Garza | MEX | Left | Right | 6' 1" | 180 lbs | - |
| Sosa, Ramón | LF | Myrtle Beach Knockouts | 26 | 10/24/1997 | North Lauderdale | USA | Left | Left | 6' 4" | 230 lbs | - |
| Soto, Emílio | CF | Kinston Saloons | 21 | 03/12/2002 | La Romana | DOM | Left | Right | 6' 4" | 185 lbs | - |
| Soto, Júlio | RP | Salem Cannibals | 22 | 03/23/2001 | Mao | DOM | Left | Left | 5' 11" | 160 lbs | - |
| Soto, Sixto | SP | Potomac Blue Demons | 24 | 10/27/1999 | Corpus Christi | USA | Right | Right | 6' 3" | 210 lbs | - |
| Sousa, Albert | CF | Salem Cannibals | 21 | 03/20/2002 | Puebla | MEX | Left | Left | 5' 10" | 160 lbs | - |
| Spencer, Bill | RP | Kinston Saloons | 25 | 02/28/1998 | Huntersville | USA | Right | Right | 6' 1" | 225 lbs | - |
| Spencer, Duane | LF | Frederick Sea Eagles | 23 | 01/26/2000 | Fullerton | USA | Left | Right | 6' 1" | 190 lbs | - |
| Stewart, Ernest | SP | Winston-Salem Wheelers | 23 | 01/03/2001 | Fort Myers | USA | Right | Right | 5' 10" | 175 lbs | - |
| Sullivan, Willie | 1B | Frederick Sea Eagles | 27 | 03/20/1996 | Raleigh | USA | Switch | Right | 6' 2" | 245 lbs | - |
