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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Ernesto | SP | Clearwater Evaders | 21 | 02/16/2002 | Havana | CUB | Right | Right | 6' 5" | 205 lbs | - |
| Saldaña, Lorenzo | CL | Dunedin Sandtigers | 22 | 09/04/2001 | Paterson | USA | Right | Right | 6' 4" | 200 lbs | - |
| Samurakami, Shusaku | RP | Clearwater Evaders | 24 | 04/05/1999 | Fukuoka | JPN | Right | Right | 6' 4" | 215 lbs | - |
| Sánchez, Felipe | 1B | Lakeland Hillbillies | 20 | 07/31/2003 | Santo Domingo | DOM | Right | Left | 6' 4" | 205 lbs | - |
| Sánchez, José | C | Tampa Ospreys | 26 | 07/08/1997 | Houston | USA | Right | Right | 6' 0" | 235 lbs | - |
| Sánchez, José | 2B | Free Agent | 28 | 07/30/1995 | Lawrence | USA | Right | Right | 6' 3" | 235 lbs | - |
| Sanders, Kenny | C | Vero Beach Homesteads | 26 | 08/05/1997 | Marietta | USA | Right | Right | 6' 1" | 230 lbs | - |
| Sandoval, Júlio | RP | Fort Myers Millers | 25 | 08/15/1998 | Peterborough | USA | Right | Right | 6' 4" | 215 lbs | - |
| Sasaki, Ryutaro | RP | Dunedin Sandtigers | 23 | 02/11/2000 | Nabari | JPN | Right | Right | 6' 0" | 180 lbs | - |
| Sato, Seishiro | C | Brevard County Spin Doctors | 24 | 10/03/1999 | Owase | JPN | Right | Right | 6' 2" | 225 lbs | - |
| Schmidt, Chris | LF | Clearwater Evaders | 24 | 10/08/1999 | Wellsville | USA | Right | Right | 6' 2" | 195 lbs | - |
| Scott, Joe | RP | Clearwater Evaders | 23 | 02/05/2000 | Folsom | USA | Right | Right | 6' 1" | 185 lbs | - |
| Sepúlveda, Mario | SS | Free Agent | 26 | 10/06/1997 | Acapulco | MEX | Right | Right | 6' 1" | 200 lbs | - |
| Shawver, Paul | SP | Vero Beach Homesteads | 21 | 02/23/2002 | Austintown | USA | Right | Right | 6' 1" | 185 lbs | - |
| Sherman, Bill | RP | Daytona Alpines | 24 | 05/13/1999 | Niles | USA | Right | Right | 6' 6" | 215 lbs | - |
| Shoemaker, Kurt | RP | Free Agent | 26 | 04/11/1997 | North Oaks | USA | Left | Right | 6' 6" | 200 lbs | - |
| Short, Fred | CL | Daytona Alpines | 23 | 10/02/2000 | Chandler | USA | Right | Right | 6' 3" | 200 lbs | - |
| Silva, Jorge | RP | Lakeland Hillbillies | 22 | 08/29/2001 | Bonao | DOM | Left | Left | 6' 1" | 175 lbs | - |
| Simpson, Carl | SP | Clearwater Evaders | 24 | 06/20/1999 | Santa Ana | USA | Switch | Right | 6' 1" | 200 lbs | - |
| Sizemore, Erik | SP | Fort Myers Millers | 23 | 05/20/2000 | Las Vegas | USA | Left | Left | 6' 6" | 210 lbs | - |
| Skinner, Greg | 1B | Free Agent | 28 | 09/28/1995 | Los Angeles | USA | Left | Right | 6' 3" | 235 lbs | - |
| Smart, Thomas | RF | Free Agent | 25 | 03/24/1998 | Aspen Hill | USA | Switch | Right | 6' 0" | 180 lbs | - |
| Smiley, Allen | RP | Fort Myers Millers | 23 | 05/26/2000 | Farmland | USA | Left | Right | 6' 1" | 185 lbs | - |
| Smith, Charles | RP | St. Lucie Minutemen | 24 | 06/17/1999 | Chicago | USA | Left | Left | 6' 4" | 205 lbs | - |
| Smith, Michael | RP | Brevard County Spin Doctors | 23 | 02/07/2000 | Davie | USA | Switch | Right | 6' 2" | 195 lbs | - |
| Smith, Paul | C | Brevard County Spin Doctors | 23 | 01/23/2000 | Mount Vernon | USA | Left | Right | 6' 2" | 215 lbs | - |
| Smith, Walt | 2B | Clearwater Evaders | 24 | 02/20/1999 | Dallas | USA | Left | Right | 6' 1" | 200 lbs | - |
| Snijders, Victor | SS | Dunedin Sandtigers | 21 | 06/13/2002 | Canberra | AUS | Right | Right | 6' 0" | 175 lbs | - |
| Soriano, Sixto | 3B | Free Agent | 26 | 09/17/1997 | Santo Domingo | DOM | Right | Right | 6' 0" | 200 lbs | - |
| Soto, Cristóbal | 2B | Brevard County Spin Doctors | 26 | 09/05/1997 | Paterson | USA | Right | Right | 6' 1" | 195 lbs | - |
| Stephens, Fred | 3B | Free Agent | 26 | 02/15/1997 | Lexington | USA | Right | Right | 6' 0" | 205 lbs | - |
| Stewart, David | C | Free Agent | 25 | 05/26/1998 | Topeka | USA | Right | Right | 6' 2" | 230 lbs | - |
| Suzuki Jr., Shigeaki | RP | Tampa Ospreys | 25 | 06/22/1998 | Taft | USA | Left | Left | 6' 4" | 220 lbs | - |
