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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saldaña, Bill | RP | Free Agent | 21 | 01/16/2002 | Royal Oak | USA | Left | Left | 6' 8" | 220 lbs | - |
| Sánchez, Francisco | RP | Greenville Cattlemen | 23 | 02/27/2000 | Sterling | USA | Switch | Right | 6' 0" | 195 lbs | - |
| Sánchez, Jesús | 1B | Elizabethton Yellows | 25 | 08/29/1998 | Grosse Pointe Woods | USA | Left | Right | 6' 4" | 215 lbs | - |
| Sandoval, Manuel | 3B | Bristol Guerillas | 23 | 03/01/2000 | Coatzacoalcos | MEX | Switch | Right | 6' 1" | 190 lbs | - |
| Santos, Luis | CF | Free Agent | 22 | 07/13/2001 | San Juan | PUR | Right | Right | 6' 4" | 190 lbs | - |
| Savage, Cade | RP | Princeton Disciples | 23 | 06/14/2000 | Philadelphia | USA | Right | Right | 6' 2" | 205 lbs | - |
| Schmidt, Arnold | LF | Bristol Guerillas | 26 | 09/14/1997 | San Marcos | USA | Right | Right | 6' 0" | 205 lbs | - |
| Schmitt, Seth | C | Bristol Guerillas | 24 | 09/05/1999 | Brooklyn | USA | Right | Right | 6' 3" | 235 lbs | - |
| Schroeder, Mike | 2B | Burlington Timberjacks | 22 | 05/10/2001 | Glen Allen | USA | Switch | Right | 5' 9" | 165 lbs | - |
| Schultz, Peter | C | Bristol Guerillas | 23 | 04/21/2000 | Orem | USA | Right | Right | 6' 1" | 220 lbs | - |
| Scott, Mark | RP | Elizabethton Yellows | 20 | 01/25/2003 | New York | USA | Right | Right | 6' 7" | 210 lbs | - |
| Segura, Jesús | 2B | Pulaski Copperheads | 20 | 02/15/2003 | Río Grande | PUR | Right | Right | 6' 2" | 185 lbs | - |
| Shaw, Phil | SP | Johnson City Moose | 23 | 09/07/2000 | Houston | USA | Left | Left | 6' 2" | 195 lbs | - |
| Shimizu, Masaaki | RP | Free Agent | 21 | 09/23/2002 | Tsu | JPN | Left | Left | 6' 2" | 185 lbs | - |
| Silva, Jesús | CL | Danville Samurai | 22 | 07/12/2001 | Visalia | USA | Right | Right | 6' 2" | 195 lbs | - |
| Simmons, Robert | SP | Burlington Timberjacks | 24 | 09/07/1999 | New York | USA | Switch | Right | 6' 2" | 200 lbs | - |
| Sloan, Frank | 3B | Bluefield Ventures | 19 | 04/10/2004 | Hollins | USA | Right | Right | 6' 2" | 190 lbs | - |
| Smith, Lucas | 1B | Danville Samurai | 23 | 11/27/2000 | Corcoran | USA | Right | Right | 6' 0" | 210 lbs | - |
| Soto, José | LF | Johnson City Moose | 24 | 04/26/1999 | Eugene | USA | Right | Right | 6' 0" | 185 lbs | - |
| Sparks, Tom | RP | Pulaski Copperheads | 22 | 10/25/2001 | Sandy Valley | USA | Right | Right | 6' 2" | 205 lbs | - |
| Spencer, Ronald | C | Bristol Guerillas | 22 | 04/11/2001 | Los Angeles | USA | Right | Right | 6' 3" | 215 lbs | - |
| Stephens, Jack | SP | Danville Samurai | 20 | 05/06/2003 | San Diego | USA | Left | Left | 6' 4" | 190 lbs | - |
| Stephens, Norm | SS | Greenville Cattlemen | 20 | 09/25/2003 | Winston-Salem | USA | Right | Right | 6' 3" | 190 lbs | - |
| Stewart, Artie | 1B | Bristol Guerillas | 20 | 09/08/2003 | Wayne | USA | Switch | Right | 6' 4" | 210 lbs | - |
| Stewart, Pat | 3B | Kingsport Inferno | 23 | 12/13/2000 | Carol Stream | USA | Right | Right | 6' 0" | 210 lbs | - |
| Stokes, Kurt | C | Kingsport Inferno | 22 | 05/23/2001 | New York | USA | Right | Right | 6' 1" | 205 lbs | - |
| Stone, Jeremy | SS | Burlington Timberjacks | 22 | 10/30/2001 | Greer | USA | Right | Right | 5' 9" | 165 lbs | - |
| Strickland, Erwin | CF | Johnson City Moose | 22 | 09/29/2001 | Dallas | USA | Right | Right | 6' 0" | 190 lbs | - |
| Stroud, Alan | RF | Burlington Timberjacks | 20 | 06/14/2003 | Grapevine | USA | Right | Right | 6' 3" | 190 lbs | - |
| Sugiura, Shimei | 1B | Danville Samurai | 22 | 07/13/2001 | Nagoya | JPN | Left | Right | 6' 2" | 230 lbs | - |
| Suitani, Shusaku | RP | Elizabethton Yellows | 21 | 06/20/2002 | Oyama | JPN | Left | Right | 6' 0" | 175 lbs | - |
| Swanson, Bryan | 2B | Bluefield Ventures | 22 | 06/11/2001 | Weston | USA | Right | Right | 6' 2" | 190 lbs | - |
